Beyond thalidomide: birth defects explained
Beyond thalidomide: birth defects explained
Janet McCredie
The Royal Society of Medicine Press
ISBN: 9781853157417


How do birth defects happen? What goes wrong in the embryo? These perennial questions were brought into sharp focus in the wake of the thalidomide catastrophe (1958–1962). How did thalidomide mutilate the embryo? Despite research efforts, these questions have remained unanswered.

Beyond thalidomide examines the neural crest theory in breadth and depth, incorporating evidence from clinical medicine, radiology, biology, pharmacology, neurology, neuroanatomy and neuropathology. Key publications, some now out of print, are restored to their rightful places in the thalidomide saga and background information is provided to help the general reader gain a better understanding of the sciences involved. It will be of particular interest to those involved with birth defects – obstetricians, neonatologists, paediatricians – and also neurologists, scientists in teratology and developmental biology, and thalidomiders themselves.

Unfortunately no trade discount can be offered for this title.

For a great introduction into the origins and history of thalidomide see Janet McCredie’s article “History, heresy and radiology in scientific discovery“ Journal of Medical Imaging and Radiation Oncology, 53(5): 433–41, October 2009. A short history of thalidomide and Dr McCredie’s research into the neural crest theory can be found on the Sydney Publishing blog.

Digital editions

A free PDF version of the book can be downloaded here.

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Hard cover